Molecular profiling of breast cancer: portraits but not physiognomy
Open Access
- 1 January 2001
- journal article
- review article
- Published by Springer Nature in Breast Cancer Research
- Vol. 3 (2), 77-80
- https://doi.org/10.1186/bcr274
Abstract
Breast cancers differ in response to treatment and may have a divergent clinical course despite having a similar histopathological appearance. New technology using DNA microarrays provides a systematic method to identify key markers for prognosis and treatment response by profiling thousands of genes expressed in a single cancer. Microarray profiling of 38 invasive breast cancers now confirms striking molecular differences between ductal carcinoma specimens and suggests a new classification for oestrogen-receptor negative breast cancer. Future approaches will need to include methods for high-throughput clinical validation and the ability to analyze microscopic samples.Keywords
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