Morphologic and Biologic Correlation of Hyperplastic and Neoplastic Hepatic Lesions Occurring “Spontaneously” in C3H × Y Hybrid Mice

Abstract

Hyperplastic and neoplastic lesions of the liver occurring “spontaneously” in C3H × Y male mice were transplanted autologously and isologously. Hyperplastic lesions did not survive in the same animal or in other animals of the same strain. Carcinomas grew in the host or in isologous mice and killed the animals. Most of the lesions were hyperplastic, and few were carcinomas. It is concluded that the histologic pattern of hyperplastic and neoplastic lesions can be correlated with the results obtained on transplantation.