Structure-based Mutagenesis Reveals Distinct Functions for Ras Switch 1 and Switch 2 in Sos-catalyzed Guanine Nucleotide Exchange
Open Access
- 1 July 2001
- journal article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 276 (29), 27629-27637
- https://doi.org/10.1074/jbc.m101727200
Abstract
No abstract availableKeywords
This publication has 46 references indexed in Scilit:
- Functional Roles for the Pleckstrin and Dbl Homology Regions in the Ras Exchange Factor Son-of-sevenlessPublished by Elsevier ,1995
- In Vivo Functional Analysis of the Ras Exchange Factor Son of SevenlessScience, 1995
- The Sos (Son of sevenless) proteinTrends in Endocrinology & Metabolism, 1994
- Chromosomal localization of two genes encoding human ras exchange factors: SOS1 maps to the 2p22→p16 region and SOS2 to the 14q21→q22 region of the human genomeCytogenetic and Genome Research, 1994
- Proteins regulating Ras and its relativesNature, 1993
- Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factorCell, 1993
- Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformationNature, 1993
- Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on RasNature, 1993
- Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signallingNature, 1993
- The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1Nature, 1993