Aminopterin and Response of Frog Oviducts to Estradiol. II. Histological Studies and Mitotic Counts.

Abstract

Both macro-scopically and microscopically, the oviducts of frogs receiving aminopterin (4-amino-pteroglutamic acid) failed to respond to the growth stimulating action of estradiol, but a significantly greater number of mitotic figures were visible in the ducts. The folic acid antagonists may exert their growth-inhibiting action by interfering with folic acid utilization in the organism, with a consequent reduction in nucleic acid synthesis and a retardation of the rate of cell division.