Dealkylation studies on inhibited acetylcholinesterase
- 1 March 1966
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 98 (3), 869-873
- https://doi.org/10.1042/bj0980869
Abstract
A rapid method for measuring the rate of dealkylation of organophosporus-inhibited enzymes is described. The dealkylation rates have been measured for acetylcholinesterase inhibited by iso-propyl, sec.-butyl, 1,2-dimethylpropyl,1,2,2-trimethylpropyl and cyclohexyl methylphosphonofluoridate, and by diisopropyl phosphoro-fluoridate; they are 1st-order under the conditions used.This publication has 7 references indexed in Scilit:
- Dealkylation as a mechanism for aging of cholinesterase after poisoning with pinacolyl methylphosphonofluoridateBiochemical Pharmacology, 1965
- Antidotal action of pyridinium oximes in anticholinesterase poisoning; Comparative effects of soman, sarin, and neostigmine on neuromuscular functionToxicology and Applied Pharmacology, 1963
- Chemical nature of the DFP-binding site of pseudocholinesteraseBiochimica et Biophysica Acta, 1959
- PROTECTION AGAINST THE LETHAL EFFECTS OF ORGANO‐PHOSPHATES BY PYRIDINE‐2‐ALDOXIME METHIODIDEBritish Journal of Pharmacology and Chemotherapy, 1957
- THE REACTIVATION BY OXIMES AND HYDROXAMIC ACIDS OF CHOLINESTERASE INHIBITED BY ORGANO‐PHOSPHORUS COMPOUNDSBritish Journal of Pharmacology and Chemotherapy, 1955
- EFFECT OF NICOTINHYDROXAMIC ACID METHIODIDE ON HUMAN PLASMA CHOLINESTERASE INHIBITED BY ORGANOPHOSPHATES CONTAINING A DIALKYLPHOSPHATO GROUPBritish Journal of Pharmacology and Chemotherapy, 1955
- The mechanism of inhibition of cholinesterases by organophosphorus compoundsBiochemical Journal, 1953