Gene for lipoamide dehydrogenase maps to human chromosome 7
- 1 July 1988
- journal article
- research article
- Published by Springer Science and Business Media LLC in Somatic Cell and Molecular Genetics
- Vol. 14 (4), 411-414
- https://doi.org/10.1007/bf01534650
Abstract
The gene for lipoamide dehydrogenase (LD) has been assigned to human chromosome 7 based on filter hybridization analysis of genomic DNA from rodent-human somatic cell hybrids using a cDNA probe for human LD. No indication of multiple copies of the gene was found, in accordance with previous evidence that LD in the pyruvate, α-ketoglutarate, and branched chain α-ketoacid dehydrogenase complexes is genetically as well as biochemically identical.Keywords
This publication has 19 references indexed in Scilit:
- Rat liver mitochondria contain two immunologically distinct dihydrolipoamide dehydrogenasesArchives of Biochemistry and Biophysics, 1987
- A decrease in glycine cleavage activity in the liver of a patient with dihydrolipoyl dehydrogenase deficiencyJournal of Inherited Metabolic Disease, 1986
- Inhibition of glycine oxidation by pyruvate, α-ketoglutarate, and branched-chain α-keto acids in rat liver mitochondria: Presence of interaction between the glycine cleavage system and α-keto acid dehydrogenase complexesArchives of Biochemistry and Biophysics, 1986
- Assignment of the Gene for Myelin Proteolipid Protein to the X Chromosome: Implications for X-Linked Myelin DisordersScience, 1985
- Pyruvate dehydrogenase subcomplex with lipoamide dehydrogenase deficiency in a patient with lactic acidosis and branched chain ketoaciduriaClinica Chimica Acta; International Journal of Clinical Chemistry, 1984
- Nucleotide sequence of the lipoamide dehydrogenase gene of Escherichia coli K12European Journal of Biochemistry, 1983
- Studies of urinary organic acid profiles of a patient with dihydrolipoyl dehydrogenase deficiencyClinica Chimica Acta; International Journal of Clinical Chemistry, 1983
- The Pyruvate Dehydrogenase Complex of Escherichia coli K12European Journal of Biochemistry, 1983
- A Defect in Branched-Chain Amino Acid Metabolism in a Patient with Congenital Lactic Acidosis due to Dihydrolipoyl Dehydrogenase DeficiencyPediatric Research, 1978
- Deficiency of Dihydrolipoyl Dehydrogenase (a Component of the Pyruvate and α-Ketoglutarate Dehydrogenase Complexes): A Cause of Congenital Chronic Lactic Acidosis in InfancyPediatric Research, 1977