Degradation Rate in Rat Liver Homogenate in Relation to Antibacterial Activity of Various Nitrofuran Derivatives

Abstract

Fourteen nitrofuran derivatives were comparatively examined for the ratio of their degradation rate in rat liver homogenates to their corresponding antibacterial activities. Results are shown in Table I and Fig. 1. This ratio probably indicates whether a sample should be used as a chemotherapeutic (when the ratio is more than 2) or as a preservative (when less than 1). Discussions were given about this relationship.