Expression of HCV E2/NS1 protein as a fusion protein with maltose binding protein: detection of anti-E2/NS1 antibody in chronic liver disease.
Open Access
- 1 January 1993
- Vol. 34 (2 Suppl), S64-S65
- https://doi.org/10.1136/gut.34.2_suppl.s64
Abstract
The presence of anti-E2 antibody was investigated in the serum samples of 46 patients with liver disease, who were positive for hepatitis C virus-RNA, and in five subjects HCV-RNA-negative acting as controls. Antibody to E2/NS1 protein was found in seven of 46 (15%) of the patients with liver disease but in none of the control subjects. In one patient who was treated successfully with interferon, the levels of anti-E2 gradually decreased and then finally disappeared after treatment. This suggests that the E2/NS1 protein may play a role in active viral replication.Keywords
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