STUDIES ON THE PREVENTION OF SENSITIZATION BY BORDETELLA PERTUSSIS IN ALLOXAN DIABETIC MICE

Abstract

Data are presented which indicate that, in mice, alloxan-induced diabetes inhibits the sensitizing properties of Bordetella pertussis as measured by challenge with histamine, serotonin, and induction of anaphylaxis. This effect of alloxan is reversed by insulin, thereby ruling out non-specific toxicity as the cause of the observed inhibitory reaction.The possible mechanism of the inhibitory action of alloxan diabetes on pertussis sensitization is discussed.