THE INACTIVATION OF THYROTROPHIN RELEASING HORMONE BY PLASMA IN THYROID DISEASE
- 1 May 1975
- journal article
- Published by Wiley in Clinical Endocrinology
- Vol. 4 (3), 231-236
- https://doi.org/10.1111/j.1365-2265.1975.tb01530.x
Abstract
The inactivation of immunoreactive TRH in vitro by human plasma has been investigated. In a preliminary study, 2.5 ng TRH was destroyed by 50 mul plasma at a mean rate of 1.7%/min in eight subjects. The per cent inactivation of the same amount of TRH at three plasma dose levels was measured after 60 min in seventy unselected patients attending a thyroid clinic. There was no significant difference in the results obtained in those subsequently shown to be euthyroid (forty-three patients), hyperthyroid (eighteen patients) or hypothyroid (nine subjects).Keywords
This publication has 12 references indexed in Scilit:
- USE OF BENZAMIDINE TO PREVENT THE DESTRUCTION OF THYROTROPIN-RELEASING HORMONE (TRH) BY BLOODJournal of Clinical Endocrinology & Metabolism, 1974
- RADIOIMMUNOASSAY OF THYROTROPHIN RELEASING HORMONEJournal of Endocrinology, 1973
- POSSIBLE CONTROL OF LUTEINISING-HORMONE-RELEASING HORMONE BY ENZYMATIC DEGRADATIONThe Lancet, 1973
- CONTROL OF POLYPEPTIDE HORMONES BY ENZYMATIC DEGRADATIONThe Lancet, 1973
- Factors in blood influencing the determination of thyrotropin releasing hormoneClinica Chimica Acta; International Journal of Clinical Chemistry, 1973
- THE EFFECTS OF ORCHIDECTOMY AND TESTOSTERONE PROPIONATE INJECTION ON PEPTIDASE ACTIVITY IN THE MALE RAT HYPOTHALAMUSActa Endocrinologica, 1973
- Serum Inactivation of the Immunological and Biological Activity of Thyrotropin—Releasing Hormone (TRH)Endocrinology, 1972
- THE EFFECT OF OVARIECTOMY ON THE ACTIVITY OF CERTAIN ENZYMES IN THE FEMALE RAT HYPOTHALAMUSActa Endocrinologica, 1972