XXYY VARIANT OF KLINEFELTERS SYNDROME
- 1 January 1964
- journal article
- research article
- Vol. 90 (9), 575-+
Abstract
Three males with an XXYY sex chromosome complex are described, who together with 5 XXYY subjects recorded in the literature, show the clinical features of Klinefelter''s syndrome. Taking into consideration the findings in XYY and XXXYY individuals, it appears that the addition of a Y chromosome to XY, XXY and XXXY complexes has a variable and as yet not clearly delineated harmful effect. For example, a 44 + XXYY complement of chromosomes may prove to have significant manifestations in skeletal maturation and predispose to vascular and cutaneous abnormalities of the lower extremities in older patients. But when two Y chromosomes are present, the phenotype does not differ markedly from that resulting from the presence of a single Y chromosome in the sex chromosome complex. This finding is compatible with the view that the Y chromosome of man is relatively inert, compared with the autosomes, except for genes that function in male sex determination.Keywords
This publication has 8 references indexed in Scilit:
- An XXXYY Sex-Chromosome AnomalyJAMA, 1963
- XYY GenotypeNew England Journal of Medicine, 1963
- 'DOUBLE MALE' – A NEW CHROMOSOME CONSTITUTION IN THE KLINEFELTER SYNDROMEActa Endocrinologica, 1962
- SEX CHROMATIN AND SEX CHROMOSOMES - ON ORIGIN OF SEX CHROMATIN FROM A SINGLE X CHROMOSOME1962
- [Kinefelter's syndrome, mental debility, discrete cerebral atrophy, karyotype XX YY].1961
- A probable XXYY sex determining mechanism in a mentally defective male with Klinefelter's syndrome.1961
- THE MENTAL LEVEL IN 47 CASES OF »TRUE KLINEFELTER'S SYNDROME«Acta Endocrinologica, 1961
- PRIMARY AMENTIA AND MICRO-ORCHIDISM ASSOCIATED WITH AN XXXY SEX-CHROMOSOME CONSTITUTIONThe Lancet, 1960