Soft-tissue Effects Following 224Ra Injections Into Humans

Abstract
Following the Second World War, repeated intravenous injections of 224Ra (ThX) were given to German children and adults for the intended treatment of tuberculosis, ankylosing spondylitis, and a few other diseases. We have ascertained the health status of 204 juveniles and 612 adults for whom both dosage and injection span are known. 224Ra is known as a “skeletal-seeker”, and has induced malignant bone sarcomas, benign exostoses, tooth breakage, and growth retardation. But because of its short 3.62-day half-life, 224Ra also decays to an appreciable extent in soft tissues, as do the injected atoms of its decay products. In the present article we present evidence suggesting that some, but certainly not all, of the observed cases of soft-tissue neoplasms, kidney diseases, liver cirrhosis, and cataracts may be related to the 224Ra therapy. Of particular interest are the 8 cases of cataracts reported at 14–46 years of age (33 yr average) among the 204 patients injected with 224Ra as juveniles. Due to the rarity of “naturally-occurring” cataracts at young ages, perhaps all of these 8 cases can be regarded as induced.