AMNIOTIC FLUlD α1 FETOPROTEIN IN THE DIAGNOSIS OF NEURAL TRACT MALFORMATIONS
- 1 April 1975
- journal article
- Published by Wiley in BJOG: An International Journal of Obstetrics and Gynaecology
- Vol. 82 (4), 257-261
- https://doi.org/10.1111/j.1471-0528.1975.tb00630.x
Abstract
Amniotic fluid alpha1fetoprotein levels were determined in 400 pregnancies. The normal range for alpha1fetoprotein in amniotic fluid was defined by 350 samples from normal pregnancies. Elevated levels of alpha1fetoprotein were detected in 17 out of 18 pregnancies which gave rise to infants with neural tract abnormalities. The significance of this test in the antenatal diagnosis of neural tract abnormalities is discussed together with the possible reasons for "false negative" and "false positive" results. There were no complications in an individual series of 105 consecutive amniocenteses.Keywords
This publication has 8 references indexed in Scilit:
- FALSE-POSITIVE RESULTS IN ANTENATAL DIAGNOSIS OF NEURAL-TUBE DISORDERSThe Lancet, 1974
- Alpha-Fetoprotein Levels in Amniotic Fluids from Spontaneous AbortionsBMJ, 1974
- ALPHA‐FETOPROTEIN LEVELS IN AMNIOTIC FLUID IN NORMAL PREGNANCY AND IN PREGNANCY COMPLICATED BY ANENCEPHALYBJOG: An International Journal of Obstetrics and Gynaecology, 1973
- ALPHA-FETOPROTEIN IN THE ANTENATAL DIAGNOSIS OF ANENCEPHALY AND SPINA BIFIDAThe Lancet, 1972
- POSTNATAL CHANGES OF ALPHA‐FOETOPROTEIN, ALBUMIN AND TOTAL PROTEIN IN HUMAN SERUMActa Paediatrica, 1972
- Alpha-Fetoprotein in Ontogenesis and its Association with Malignant TumorsAdvances in Cancer Research, 1971
- Sites of Serum α-Fetoprotein Synthesis in the Human and in the Rat*JCI Insight, 1967
- Serum alpha-fetoprotein, albumin, and gamma-G-globulin in the human conceptus.JCI Insight, 1966