THE INFLUENCE OF ADRENALECTOMY AND CORTICOID REPLACEMENT ON OVARIAN COMPENSATORY HYPERTROPHY IN RATS
- 1 November 1964
- journal article
- research article
- Published by Oxford University Press (OUP) in Acta Endocrinologica
- Vol. 47 (3), 485-490
- https://doi.org/10.1530/acta.0.0470485
Abstract
Adrenalectomy abolished the ovarian compensatory hypertrophy that followed unilateral castration in rats. Maintenance of the animals with saline to drink or with injected cortisol or deoxycorticosterone restored the response. These data are interpreted as follows: the absence of cortical hormones disrupts cellular metabolism, probably at the level of the ovary, so that the ovary is not capable of a growth response to the increased gonado-tropin available after hemicastration. The data do not support the pituitary shift hypothesis of Selye (1950).Keywords
This publication has 5 references indexed in Scilit:
- STEROID-INDUCED BLOCK OF OVARIAN COMPENSATORY HYPERTROPHY IN HEMICASTRATED FEMALE RATSJournal of Endocrinology, 1964
- THE »EARLY-ANDROGEN« SYNDROME; ITS DEVELOPMENT AND THE RESPONSE TO HEMI-SPAYINGActa Endocrinologica, 1964
- Compensatory Hypertrophy of the Thyroid Gland, Adrenal Gland and the Gonad Studied Singly or in CombinationEndocrinology, 1963
- Effects of Adrenal Androgens on Parabiotic MiceEndocrinology, 1963
- Effects of Adrenal Androgens on Immature Female MiceEndocrinology, 1963