Ir gene controlled carrier effects in the induction and elicitation of hapten-specific delayed-type hypersensitivity responses.
Open Access
- 1 November 1979
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 150 (5), 1255-1259
- https://doi.org/10.1084/jem.150.5.1255
Abstract
The genetic requirements of carrier recognition were examined in the priming and elicitation of hapten specific, T [thymus-derived] cell mediated, delayed-type hypersensitivity (DTH) responses. Nitrophenyl acetyl-poly-(L-Glu56-L-Lys35-L-Phe9) (NP- .**GRAPHIC**. could prime for NP responses only in strains of mice which are Ir gene responders to .**GRAPHIC**. In contrast to this requirement, .**GRAPHIC**. could elicit an NP-specific response in NP-bovine .gamma.-globulin primed mice, even in .**GRAPHIC**. nonresponder strains. The nonimmunogenic molecule, NP-GL, could elicit an NP-specific DTH response in animals primed with NP on an immunogenic carrier.This publication has 5 references indexed in Scilit:
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