Apolipoprotein gene cluster on chromosome 19
- 1 January 1988
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 78 (1), 90-93
- https://doi.org/10.1007/bf00291243
Abstract
Recently, using an APOE cDNA probe, we discovered an Hpa I restriction fragment length polymorphism (RFLP) that appeared to be strongly associated with the expression of type III hyperlipoproteinemia (Klasen et al. 1987). In the present report it is shown that the same Hpa I RFLP can be revealed with both the APOC1 and APOC2 cDNA probes. This enabled us to localize the polymorphic Hpa I site between the APOE and APOC1 genes and to localize the APOC2 gene approximately 22 kb 3′ of the APOC1 pseudogene on chromosome 19.Keywords
This publication has 27 references indexed in Scilit:
- A common restriction fragment length polymorphism of the human apolipoprotein E gene and its relationship to type III hyperlipidaemiaHuman Genetics, 1987
- The gene for human apolipoprotein CI is located 4.3 kilobases away from the apolipoprotein E gene on chromosome 19Human Genetics, 1986
- Structure, evolution, and tissue-specific synthesis of human apolipoprotein AIVBiochemistry, 1986
- There are two gene sequences for human apolipoprotein CI (apo CI) on chromosome 19, one of which is 4 KB from the gene for apo EBiochemical and Biophysical Research Communications, 1986
- Structure and evolution of the apolipoprotein multigene familyJournal of Molecular Biology, 1986
- Isolation of probes detecting restriction fragment length polymorphisms from X chromosome-specific libraries: potential use for diagnosis of Duchenne muscular dystrophyHuman Genetics, 1985
- Linkage relationships of the gene for apolipoprotein CII with loci on chromosome 19Human Genetics, 1985
- The gene for apolipoprotein C‐ll is closely linked to the gene for apolipoprotein E on chromosome 19Clinical Genetics, 1984
- Human apolipoprotein A-I--C-III gene complex is located on chromosome 11.Arteriosclerosis: An Official Journal of the American Heart Association, Inc., 1984
- The locus for apolipoprotein E (apoE) is linked to the complement component C3 (C3) locus on chromosome 19 in manHuman Genetics, 1982