Functional neuroimaging studies in posttraumatic stress disorder: review of current methods and findings
- 7 September 2006
- journal article
- review article
- Published by Hindawi Limited in Depression and Anxiety
- Vol. 24 (3), 202-218
- https://doi.org/10.1002/da.20208
Abstract
Posttraumatic stress disorder (PTSD) is an anxiety disorder associated with changes in neural circuitry involving frontal and limbic systems. Altered metabolism in these brain structures after a traumatic event is correlated to PTSD. Developments in the field of neuroimaging have allowed researchers to look at the structural and functional properties of the brain in PTSD. Despite the relative novelty of functional imaging and its application to the field of PTSD, numerous publications have brought to light several of the circuits implied in this disorder. This article summarizes the findings with regard to PTSD in the functional imaging techniques of single‐photon emission computed tomography (SPECT), positron emission tomography (PET), and functional magnetic resonance imaging (fMRI). Furthermore, we discuss strengths and weaknesses of the various techniques and studies. Finally, we explore the future potential of functional neuroimaging studies in PTSD. Depression and Anxiety 24:202–218, 2007. Published 2006 Wiley‐Liss, Inc.Keywords
This publication has 78 references indexed in Scilit:
- A functional MRI comparison of patients with obsessive–compulsive disorder and normal controls during a Chinese character Stroop taskPsychiatry Research: Neuroimaging, 2005
- No Change in Serotonin Type 1A Receptor Binding in Patients With Posttraumatic Stress DisorderAmerican Journal of Psychiatry, 2005
- Evidence of early neurobiological alternations in adolescents with posttraumatic stress disorder: a functional MRI studyNeuroscience Letters, 2004
- Single photon emission computed tomography in posttraumatic stress disorder before and after treatment with a selective serotonin reuptake inhibitorJournal of Affective Disorders, 2004
- Selectively reduced regional cortical volumes in post-traumatic stress disorderNeuroReport, 2003
- MRI and PET Study of Deficits in Hippocampal Structure and Function in Women With Childhood Sexual Abuse and Posttraumatic Stress DisorderAmerican Journal of Psychiatry, 2003
- Neural Correlates of Traumatic Recall in Posttraumatic Stress DisorderStress, 2003
- Neural Correlates of Traumatic Memories in Posttraumatic Stress Disorder: A Functional MRI InvestigationAmerican Journal of Psychiatry, 2001
- Brain blood flow in anxiety disordersThe British Journal of Psychiatry, 1997
- Functional neuroanatomical correlates of the effects of stress on memoryJournal of Traumatic Stress, 1995