Structural Causes of Cardiac Dysfunction in Uremia
- 1 January 1993
- journal article
- research article
- Published by Taylor & Francis in Renal Failure
- Vol. 15 (3), 421-428
- https://doi.org/10.3109/08860229309054955
Abstract
While coronary heart disease is undoubtedly a major cause of cardiac morbidity and mortality in uremia, important noncoronary problems contribute to the common presence of cardiac problems. Based on clinical and experimental studies, we could show: (i) Left ventricular hypertrophy (LVH) can be dissociated, at least in part, from elevation of blood pressure, (ii) In uremia, PTH-dependent intermyo-cardiocytic fibrosis occurs; it may account, at least in part, for disturbed LV compliance and contribute to the arrhythmogenic potential. (iii) Blood pressure-independent abnormalities of intracardiac arterioles and reduced myocardial capillary supply are observed.Keywords
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