THE RÔLES OF ANTERIOR PITUITARY AND THYROID IN THE STIMULATION OF TISSUE METABOLISM FOLLOWING THEELIN ADMINISTRATION

Abstract

Theelin administration in spayed rats increases the metabolism of the ant. pituitary in 6 and the liver in 72 hrs. This effect on the liver is abolished by hypophysectomy or thyroidectomy. Thyroxin inj. increases the liver metabolism of spayed rats in 48 hrs.; ant. pituitary extract increases it in 72 hrs. The increased metabolism of the liver of spayed rats injected with theelin or amniotin results from the action of theelin on the anterior hypophysis. The pituitary secretion stimulates thyroid activity which results in increased tissue metabolism. The effect of theelin on liver metabolism is mediated through the ant. pituitary and thyroid, whereas its metabolic action on the ant. pituitary is direct.