Postnatal Changes in the Pituitary-Adrenal Axis of the Rat
- 1 May 1968
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 128 (1), 269-272
- https://doi.org/10.3181/00379727-128-32994
Abstract
Compensatory adrenal hypertrophy following unilateral adrenalectomy was studied in rats from day 2 to day 30 of life. The response followed a biphasic pattern, being 18.2% on day 2, 4.5% on day 7 and 20.0% by day 30. Intermediate ages showed values intermediate to these. When 2, 7 and 21 day old rats were tested for adrenal hypertrophy following ACTH injection, a biphasic curve was again found, with a peak at day 7. The diminished response to compensatory hypertrophy on day 7 linked with greater sensitivity to exogenous ACTH indicates that the endogenous ACTH is absent or greatly diminished in this animal.This publication has 11 references indexed in Scilit:
- Adrenal and Plasma Corticosterone and Vitamin A in Rat Adrenal Glands During Postnatal DevelopmentEndocrinology, 1967
- Physiological and behavioral effects of infantile stimulationPhysiology & Behavior, 1967
- Response of the Adrenal Cortex of the Neonatal Rat after Subjection to StressNature, 1966
- Response of the Infantile Rat to StressEndocrinology, 1966
- PERINATAL THYROID FUNCTION IN THE RATActa Endocrinologica, 1966
- Compensatory Hypertrophy of Right Adrenal after Left Adrenalectomy: Observations in Fetal, Newborn and Week-old Rats.Experimental Biology and Medicine, 1964
- Studies of the Pituitary-Adrenocortical System in the Fetal RatEndocrinology, 1962
- THE DEVELOPMENT OF THE BLOOD SUPPLY OF THE PITUITARY IN THE ALBINO RAT, WITH SPECIAL REFERENCE TO THE PORTAL VESSELS1957
- Compensatory Hypertrophy of the Intact Adrenal of Fetal Rats Subjected to Unilateral Adrenalectomy.Experimental Biology and Medicine, 1950
- The Pituitary-Adrenal Relationship in the Infant RatExperimental Biology and Medicine, 1949