The rapid detection of unknown mutations in nucleic acids
- 1 October 1993
- journal article
- review article
- Published by Springer Nature in Nature Genetics
- Vol. 5 (2), 111-117
- https://doi.org/10.1038/ng1093-111
Abstract
The task of identifying mutations in nucleic acid sequences is a vital component of research in mammalian genetics. With the advent of the polymerase chain reaction, several useful mutation detection techniques have evolved in recent years. The different methods have complementing strengths and a suitable procedure for virtually any experimental situation is now available.Keywords
This publication has 57 references indexed in Scilit:
- Detection of single DNA base mutations with mismatch repair enzymesGenomics, 1992
- Eight novel inactivating germ line mutations at the APC gene identified by denaturing gradient gel electrophoresisGenomics, 1992
- Dideoxy fingerprinting (ddF): A rapid and efficient screen for the presence of mutationsGenomics, 1992
- Strand-separating conformational polymorphism analysis: Efficacy of detection of point mutations in the human ornithine δ-aminotransferase geneGenomics, 1992
- Nonisotopic SSCP detection in PCR products by ethidium bromide stainingTrends in Genetics, 1992
- High‐sensitive fluorescent DNA sequencing and its application for detection and mass‐screening of point mutationsElectrophoresis, 1992
- A one-step efficient and specific non-radioactive non-fluorescent method for in situ hybridization of banded chromosomesChromosoma, 1990
- A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motifNature, 1990
- Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms.Proceedings of the National Academy of Sciences, 1989
- Molecular heterogeneity of steroid sulfatase deficiency: A multicenter study on 57 unrelated patients, at DNA and protein levelsGenomics, 1989