Prescribing of Chloramphenicol in Ambulatory Practice

Abstract

During the 1-yr period from July 1973-June 1974, 1761 chloramphenicol prescriptions were written for 992 outpatients in the Tennessee [USA] Medicaid program. Of participating physicians, 6% (205 of 3409) prescribed chloramphenicol; 20 physicians wrote 55% of the prescriptions. Family practice and rural location were independently associated with increased rates of prescribing chloramphenicol for outpatients. Among rural family practitioners, 21% prescribed chloramphenicol. Physicians graduating since 1955 were as likely to have prescribed chloramphenicol as were earlier graduates. Almost half the adult patients received 6 g or less; 2 received more than 250 g. About half of the prescriptions were for treatment of upper respiratory infections. Most prescriptions were interdicted by good medical practice. Analysis of the prescribing of chloramphenicol (and perhaps other drugs) in ambulatory practice will help identify those physicians most in need of remedial medical education.