Ligand-Free Palladium-Catalyzed Cyanation of Aryl Halides
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- 26 January 2005
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 70 (4), 1508-1510
- https://doi.org/10.1021/jo0481250
Abstract
A practical, ligand-free cyanation of aryl bromides that utilizes as little as 0.1 mol % Pd(OAc)2 in combination with a nontoxic cyanide source, M4[Fe(CN)6] (M = K, Na), is described. The reactions are performed in DMAC at 120 °C and provide the corresponding aryl nitrile in 83−96% yield, typically in less than 5 h. TON values of up to 7100 were attained.Keywords
This publication has 3 references indexed in Scilit:
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