Synergistic Action of Erythromycin and Cefamandole Against Bacteroides fragilis Subsp. fragilis
Open Access
- 1 May 1977
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 11 (5), 813-816
- https://doi.org/10.1128/aac.11.5.813
Abstract
Erythromycin and cefamandole have exhibited synergistic activity against eight strains of Bacteroides fragilis subsp. fragilis. In concentrations of only 0.25 to 0.5 μg of erythromycin per ml (easily obtainable with oral therapy), less than 0.4 μg (0.015 to 1.0) of cefamandole per ml inhibited the B. fragilis strains. In the presence of the erythromycin, the potency of cefamandole was increased more than 100-fold. On the basis of the mechanism of action of these two antibiotics, the synergism may be related to inhibition of beta-lactamase formation by the erythromycin, removal of the bacterial cell wall by the cefamandole permitting erythromycin penetration to the ribosomal level, and decreasing inoculum effect.Keywords
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