Correa-Giron, E. P., R. Allen and S. E. Sulkin (Univ. of Texas Southwestern Medical School, Dallas, Texas 75235). The infectivity and pathogenesis of rabiesvirus administered orally. Amer. J. Epid., 1970, 97: 203–215.—-Five strains of rabiesvirus, four street strains and the CVS strain of fixed virus, were tested for their ability to infect mice via the oral route. The CVS strain and three of the four street virus strains produced infection in mice following ingestion of virus laden brain tissue. One street strain, isolated from the brown fat of a naturally infected insectivorous bat, was not infective when administered orally. Studies on the pathogenesis of rabies infection in mice following consumption of brain tissue infected with a strain of vampire bat origin suggested that infection could occur through the buccal and lingual mucosae, the lung, and the intestine. This rabiesvirus strain apparently resisted in vivo the action of the digestive juices for several hours. Rabiesvirus was isolated from various tissues of mice sacrificed between 10 minutes and 7 days after virus feeding, being present in suspensions made from brain, cheek and lip, tongue, lung, stomach, salivary gland, esophagus and trachea, heart, mesentery, and kidney. The presence of rabiesvirus antigen in the various tissues was demonstrated by the FA technique and was found most frequently in the cytoplasm of the cells of highly innervated tissues.