Soluble IL-2 receptor levels in serum from blood donors seropositive for HIV.
- 15 February 1988
- journal article
- research article
- Published by The American Association of Immunologists in The Journal of Immunology
- Vol. 140 (4), 1139-1141
- https://doi.org/10.4049/jimmunol.140.4.1139
Abstract
Serum levels of soluble IL-2R (sIL-2R) were measured in blood donors seropositive for HIV. Approximately one-half (53/101) of these seropositive donors exhibited increased serum sIL-2R levels compared with seronegative controls (n = 65). Further, a significant inverse correlation was observed between serum sIL-2R levels and CD4 cell levels in seropositive study participants. These findings suggest that increased serum sIL-2R levels in HIV infection may be linked to CD4 cell loss, and thus reflective of the stage of HIV-induced disease.This publication has 5 references indexed in Scilit:
- Natural History of Human Immunodeficiency Virus Infections in Hemophiliacs: Effects of T-Cell Subsets, Platelet Counts, and AgeAnnals of Internal Medicine, 1987
- The released interleukin 2 receptor binds interleukin 2 efficiently.The Journal of Immunology, 1986
- The Human Interleukin-2 Receptor: Normal and Abnormal Expression in T Cells and in Leukemias Induced by the Human T-Lymphotropic RetrovirusesAnnals of Internal Medicine, 1986
- Elevated titers of cell-free interleukin-2 receptor in serum and cerebrospinal fluid specimens of patients with acquired immunodeficiency syndromeImmunology Letters, 1986
- National Case-Control Study of Kaposi's Sarcoma and Pneumocystis carinii Pneumonia in Homosexual Men: Part 1, Epidemiologic ResultsAnnals of Internal Medicine, 1983