Spontaneous Platelet Aggregation in Cerebrovascular Disease II
- 1 January 1979
- journal article
- research article
- Published by Georg Thieme Verlag KG in Thrombosis and Haemostasis
- Vol. 41 (03), 512-522
- https://doi.org/10.1055/s-0038-1646803
Abstract
A group of 186 patients with Transient Ischaemic Attacks (TIA) or cerebral Infarction (Cl) was found to demonstrate in vitro Spontaneous Platelet Aggregation (SPA) in 39% of those studied. Of the 176 normal subjects studied the incidence of in vitro SPA was found to be 5%. Further investigation of the phenomenon of SPA revealed that: 1. it is associated with ADP-hyperaggregability, i. e. the threshold concentration to induce second wave aggregation is decreased; 2. it is dependant on the increase in pH which occurs in platelet-rich plasma stirring in an aggregometer while concurrent ADP-hyperaggregability is independant of this change in pH; 3. it is associated with malondialdehyde production and the release of endogenous 5- hydroxytryptamine; and that 4. in addition Km and Vmax values for [14C]-5HT incorporation are normal; and that 5. no gross abnormalities of the platelet membrane glycoproteins were apparent although occasionally glycoprotein III was found to be increased. This study demonstrates abnormal platelet behaviour in patients with TIA and Cl where the enzyme system involved in thromboxane production is sufficiently stimulated, by stirring alone, to induce aggregation of platelets and the release reaction. Acetylsalicylic acid abolishes SPA and prolongs the bleeding time with similar characteristics as has been described for normal individuals. Plasma (3-thromboglobulin levels are significantly increased in the patients studied. However, no correlation was established with the incidence of in vitro SPA.Keywords
This publication has 7 references indexed in Scilit:
- Increased Synthesis of Prostaglandin-E-like Material by Platelets from Patients with Diabetes MellitusNew England Journal of Medicine, 1977
- Platelet Function in HyperbetalipoproteinemiaThrombosis and Haemostasis, 1977
- Platelet membrane glycoproteins implicated in ristocetin-induced aggregation. Studies of the proteins on platelets from patients with Bernard-Soulier syndrome and von Willebrand's disease.JCI Insight, 1976
- Some effects of ionophores for divalent cations on blood platelets Comparison with the effects of thrombinBiochimica et Biophysica Acta (BBA) - General Subjects, 1974
- Effect of trypsin on the exposed polypeptides and glycoproteins in the human platelet membraneBiochemistry, 1972
- SPONTANEOUS AGGREGATION OF BLOOD PLATELETS AS A CAUSE OF IDIOPATHIC THROMBOSIS AND RECURRENT PAINFUL TOES AND FINGERSThe Lancet, 1971
- Platelet Sequestration in Man. I. Methods*JCI Insight, 1964