Amino Acids and Peptides. XVIII. Synthetic Peptides Related to N-Terminal Portion of Fibrin .ALPHA.-Chain and Their Inhibitory Effect on Fibrinogen/Thrombin Clotting.

Abstract

Peptide analogs of the N-terminal portion of fibrin alpha-chain were prepared and their inhibitory effects on fibrinogen/thrombin clotting were examined. Of the synthetic peptides, H-Gly-Pro-Arg-Pro-Pro-NH2 exhibited the most potent inhibitory effect.