DDT: A New Hypothesis of Its Mode of Action
- 30 October 1964
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 146 (3644), 657-658
- https://doi.org/10.1126/science.146.3644.657
Abstract
It is suggested that DDT and perhaps other chlorinated hydrocarbon insecticides owe their activity to the formation of a charge-transfer complex with a component of the nerve axon, with consequent disturbance of function. Experimental evidence is provided for the formation of two complexes with components of cockroach nerve; the complexes have been partially purified. Their formation is accompanied by an absorption in the 245- to 270-millimicron range.Keywords
This publication has 8 references indexed in Scilit:
- Pesticide Analysis, Gas Chromatography Retention Times and Sensitivity Data for Insecticides and HerbicidesJournal of Agricultural and Food Chemistry, 1964
- Poisoning by DDT: Relation between Clinical Signs and Concentration in Rat BrainScience, 1963
- Submolecular BiologyRadiation Research Supplement, 1960
- Structure-Toxicity in Hexachlorocyclohexane IsomersScience, 1955
- Mechanisms of insecticidal action. The structural topography theory and DDT-type compoundsArchives of Biochemistry and Biophysics, 1954
- Electrical phenomena in nerve. III. Frog sciatic nerveJournal of Cellular and Comparative Physiology, 1951
- The mode of action of certain insecticides on the arthropod nerve axonJournal of Cellular and Comparative Physiology, 1947
- The Site of Action of DDT in the CockroachScience, 1946