Measles Antibody in Patients With Multiple Sclerosis
- 1 April 1964
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 10 (4), 402-410
- https://doi.org/10.1001/archneur.1964.00460160072007
Abstract
Introduction The search for a virus as the cause of multiple sclerosis has been extensive, but inconclusive.1 Adams and Imagawa2 recently reported that: 1. Complement fixation (CF) and neutralization (Neut) tests revealed higher titers of measles antibody* in the sera of patients with multiple sclerosis than in those of a control group. 2. CF or Neut antibody for measles were present in the cerebrospinal fluid (CSF) of over 75% of the multiple sclerosis group and absent in the CSF of the control group. They did not suggest that measles was the cause of multiple sclerosis, but their findings, if reproducible, could represent an important breakthrough for further investigations of a causal or of an indirect immunological relationship. The present study was prompted by the need for independent verification of the above report, as well as the evaluation of the role of several other viruses in multiple sclerosis. MethodsKeywords
This publication has 5 references indexed in Scilit:
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- Measles Antibodies in Multiple Sclerosis.Experimental Biology and Medicine, 1962
- Hemagglutination and hemagglutination-inhibition with measles virusVirology, 1961
- STUDIES ON ACUTE DISSEMINATED ENCEPHALOMYELITIS PRODUCED EXPERIMENTALLY IN RHESUS MONKEYSThe Journal of Experimental Medicine, 1951
- Quantitative estimation of the albumin and gamma globulin in normal and pathologic cerebrospinal fluid by immunochemical methodsAmerican Journal Of Medicine, 1948