Induction of Carcinomas in the Nasal Cavity of Rats by Dioxane
Open Access
- 1 March 1970
- journal article
- research article
- Published by Springer Nature in British Journal of Cancer
- Vol. 24 (1), 164-167
- https://doi.org/10.1038/bjc.1970.19
Abstract
Six out of 120 rats fed dioxane in drinking water at levels of 0.75, 1.0, 1.4 or 1.8% developed carcinomas in the nasal cavity. Spontaneous tumors at this tissue localization have not been reported to occur in laboratory animals. The carcinomas were pre-eminently of epidermoid type with few adenocarcinomatous areas and epithelial papillomas. Four rats with carcinoma of the nasal cavity had hepatocellular carcinoma in addition.Keywords
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