Genetic hypertension in rats is accompanied by a defect in renal prostaglandin catabolism
- 1 April 1976
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 260 (5552), 582-586
- https://doi.org/10.1038/260582a0
Abstract
Noradrenaline releases prostaglandins in the kidney, and in rats these augment rather than reduce vasoconstriction produced by the amine. Homogenates of kidneys of New Zealand rats inbred for hypertension exhibit lower prostaglandin inactivation by 15-hydroxydehydrogenase than controls. Augmentation of noradrenaline vasoconstriction by the released prostaglandin is exaggerated. This biochemical defect could be the inherited abnormality primarily responsible for the development of hypertension in these animals.This publication has 21 references indexed in Scilit:
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