?9-Tetrahydrocannabinol, ethanol, and amphetamine as discriminative stimuli-generalization tests with other drugs

Abstract

Three groups of rats (A, B, C) were trained in a T-maze to discriminate between drug- and control solution-induced internal discriminative stimuli. The drugs used to induce discriminative stimuli were: δ⁹-THC, 5.0 mg/kg (Group A); ethanol, 1.2 g/kg (Group B), and amphetamine, 1.0 mg/kg (Group C). After discrimination acquisition several drugs were tested for generalization in each group. Group A was tested with δ⁸-THC, CBD, CBN, ethanol, pentobarbital, chlorpromazine, amphetamine, and apomorphine; only δ⁸-THC and CBN induced δ⁹-THC-like responses. Group B was tested with δ⁹-THC, δ⁸-THC, CBD, CBN, pentobarbital, and amphetamine; pentobarbital induced ethanol-like response. Group C was tested with δ⁹-THC, apomorphine, and ethanol; δ⁹-THC and apomorphine elicited amphetamine-like responses.