Efferent projections of the deep mesencephalic nucleus (pars lateralis) in the rat

Abstract

The projections of the lateral part of the deep mesencephalic nucleus (DMN) were traced by autoradiography and retrograde horseradish peroxidase (HRP) techniques. At the level of the DMN, projections from its lateral part crossed the midline and terminated in the medial and lateral part of the contralateral DMN. Furthermore, two labeled tracts passed rostrally from the lateral part of the DMN. One tract coursed dorsolaterally from the lateral DMN to terminate in the ipsilateral lateral thalamic nucleus. The second tract coursed ventrally and rostrally over the substantia nigra toward the ipsilateral zona incerta. At the caudal part of the zona incerta these fibers divided into two bundles. One bundle coursed superiorly to terminate bilaterally in the mediodorsal nucleus of the thalamus. The second bundle of fibers passed anteriorly to enter the ipsilateral zona incerta. Some of these fibers terminated upon neurons of the zona incerta and the ventromedial part of the subthalamic nucleus. The remaining fibers within the zona incerta coursed anteriorly to enter the internal capsule. These fibers terminated in the entopeduncular nucleus and medial part of the globus pallidus. These findings indicate that the lateral part of the DMN is likely to be involved in the ascending activating system of the reticular formation by connections with thalamic nuclei. Furthermore, the lateral part of the DMN may play a part in suprasegmental motor control via connections with rostral brain stem motor centers.