The excretion of creatin, creatinin and uric acid in the urine during the course of acute infectious fevers has been studied by Cathcart,1 Van Hoogenhuyze and Verploegh,2 af Klercher,3 Kocher,4 Shaffer,5 Ewing and Wolf,6 Shaffer and Coleman,7 and others. Their results agree as regards the finding of creatinuria, and an increased output of creatinin and of uric acid. The diets used by most investigators were at times in the course of the experiments of insufficient caloric value and not particularly rich in carbohydrates. Shaffer and Coleman have investigated the effects of high caloric diets, rich in carbohydrates, on the protein metabolism of patients with typhoid fever. They found that these diets retarded or prevented the loss of body protein in their cases. For this reason it was considered important to study the excretion of certain of the products of protein metabolism in the different varieties of acute febrile conditions at