Fifteen months ago a follow-up study was conducted on 75 cases of prostatic carcinoma treated by orchiectomy in the University Hospital, and the data published in The Journal (Dec. 5, 1942). The present report is concerned with a subsequent follow-up study made on the same series of cases, and twenty-one months or more have now elapsed in each case since operation. The advantage of following a closed series of cases until the death of the last survivor is obvious; and although this series is numerically a relatively small one, we believe that any obvious trends that are observed in its study might be of value in treating future cases. All the patients in this series except 4 had infiltrating carcinoma. Forty-three were suffering from pain, cachexia or other clinical manifestations of advanced cancer, and the remaining 32 all had obvious primary lesions but were not suffering subjective disturbance from metastases