Depression of delayed hypersensitivity by pretreatment with Freund-type adjuvants. I. Description of the phenomenon.
- 1 August 1971
- journal article
- Vol. 9 (2), 249-58
Abstract
Delayed hypersensitivity induced by antigen in Freund's complete adjuvant (FCA) can be depressed by pretreatment with FCA alone beforehand. In the guinea-pig, pretreatment with FCA depressed the 24 hr skin reactions which otherwise followed immunization with bovine γ-globulin, human serum albumin and the arsanil-N-acetyl tyrosine in FCA. The depression ranged from 25 to 75% and 4 hr skin reactions were also depressed. In contrast, haemolytic and cytophilic antibody to BGG was not depressed by pretreatment with FCA before immunization with antigen in FCA.This publication has 14 references indexed in Scilit:
- Depression of delayed hypersensitivity by pretreatment with Freund-type adjuvants. II. Mechanism of the phenomenon.1971
- Selective and specific inhibition of 24 hour skin reactions in the guinea-pig. 3. Depression of cytophilic and haemolytic antibodies by pretreatment with antigen and the effect of irradiation.1971
- Contact and delayed hypersensitivity in the mouse. 3. Depression of contact sensitivity by pre-treatment with antigen and the restoration of immune competence in tolerant mice by normal lymphoid and bone marrow cells.1970
- Effects of freund's adjuvant on adenovirus oncogenesis and antibody production in hamstersInternational Journal of Cancer, 1967
- Enhancement in hamsters of virus oncogenesis attending vaccination proceduresVirology, 1965
- IMMUNOLOGIC UNRESPONSIVENESS IN ADULT GUINEA PIG .I. SUPPRESSION OF DELAYED HYPERSENSITIVITY AND ANTIBODY FORMATION TO PROTEIN ANTIGENS1965
- The Cutaneous Reactivity of Guinea Pigs to Pure Protein AntigensInternational Archives of Allergy and Immunology, 1964
- Impairment of Immunological Reactivity in Guinea Pigs by Prior Injection of AdjuvantNature, 1962
- Prevention of Allergic Encephalomyelitis by Prior Injection of AdjuvantsNature, 1958
- MICROMETHODS FOR THE STUDY OF PROTEINS AND ANTIBODIES .1. PROCEDURE AND GENERAL APPLICATIONS OF HEMAGGLUTINATION AND HEMAGGLUTINATION-INHIBITION REACTIONS WITH TANNIC ACID AND PROTEIN-TREATED RED BLOOD CELLS1954