The Need for Calcium in Adrenomedullary Secretion Evoked by Biogenic Amines, Polypeptides, and Muscarinic Agents

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Abstract
Summary The following substances evoked catecholamine secretion from cats' adrenal glands perfused with Locke's solution: muscarine, pilocarpine, methacholine, histamine, 5-hydroxytryptamine, angiotensin, and bradykinin. This corroborates earlier findings. However, these substances had little or no effect on secretion when calcium was omitted from the perfusion medium. It is suggested that each of these drugs may act by promoting an influx of calcium into the chromaffin cells as previously proposed for acetylcholine and nicotinic drugs.