Dosage effect of SOD-A gene in 21-trisomic cells
- 1 January 1976
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 31 (2), 197-202
- https://doi.org/10.1007/bf00296146
Abstract
SOD-A activity was measured by the polarographic method of catalytic currents in 30 subjects 10–24 years of age with a karyotype 47, +21, and 30 age matched normal subjects. The ratio of the average amount of SOD-A in 21-trisomic cells to the average amount in normal cells is 1.4495. Statistical analysis confirms that this ratio does not differ significantly from the ratio 1.5 expected in the case of a simple gene dosage effect.Keywords
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