Expression of lectin‐like oxidized low density lipoprotein receptor‐1 in human and murine macrophages: upregulated expression by TNF‐α

Abstract

Uptake of oxidized low density lipoprotein (Ox‐LDL) and subsequent foam cell transformation have been implicated in early atherogenesis. Although multiple molecules, including class A and B scavenger receptors, have been identified as Ox‐LDL receptors, additional receptors may also be involved in this process. Here, we provide evidence that lectin‐like Ox‐LDL receptor‐1 (LOX‐1), a novel Ox‐LDL receptor initially identified in vascular endothelial cells, is also expressed in macrophages in humans and mice. Expression of LOX‐1 can be induced after macrophage‐like differentiation in vitro in human peripheral blood monocytes and the related cell line THP‐1 cells. Furthermore, LOX‐1 expression can also be detected in resident peritoneal macrophages, and can be upregulated by an inflammatory cytokine TNF‐α. These results suggest that LOX‐1 in macrophages may play an important role in Ox‐LDL uptake and subsequent foam cell formation in this cell type.