HUMAN β‐ENDORPHIN Immunoreactivity of Synthetic Analogs with Various Chain Lengths
- 1 March 1979
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 13 (3), 278-281
- https://doi.org/10.1111/j.1399-3011.1979.tb01880.x
Abstract
Immunoreactivity of synthetic human β-endorphin analogs with various chain lengths has been examined using a specific radioimmunoassay. It was found that β-endorphin-(1–21) and analogs of shortened chain exhibit no immunoreactivity, whereas β-endorphin-(1–15) possesses significant in vitro opiate activity. It appears that immunoreactivity of β-endorphin resides in the COOH-terminal segment of residues (22–31). The data also show the lack of correlation between opiate and immunological activities of β-endorphin.Keywords
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