Block of gating currents by ultraviolet radiation in the membrane of myelinated nerve
- 1 January 1976
- journal article
- research article
- Published by Springer Nature in Pflügers Archiv - European Journal of Physiology
- Vol. 364 (2), 143-145
- https://doi.org/10.1007/bf00585182
Abstract
The effect of ultraviolet radiation on the asymmetrical displacement currents in the membrane of the node of Ranvier was measured and compared with the ultraviolet blocking of the sodium current. Ultraviolet radiation irreversibly reduced the peak sodium current and the charge displaced during a depolarizing test pulse, the relative reduction being independent of potential. The ratio of the ultraviolet sensitivities of the sodium and the asymmetrical displacement currents is 2.3±0.2. This result suggests two independent identical gating particles per sodium channel in the membrane of myelinated nerve.Keywords
This publication has 6 references indexed in Scilit:
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- Displacement currents in the node of RanvierPflügers Archiv - European Journal of Physiology, 1975
- Selective blocking of the nodal sodium channels by ultraviolet radiationPflügers Archiv - European Journal of Physiology, 1974
- Selective blocking of the nodal sodium channels by ultraviolet radiationPflügers Archiv - European Journal of Physiology, 1974
- Modification of ionic membrane currents of ranvier nodes by UV-radiation under voltage clamp conditionsCellular and Molecular Life Sciences, 1971