Characterization of HTLV-I in a T-Cell Line Established From a Patient With Myelopathy
- 1 January 1989
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 46 (1), 35-37
- https://doi.org/10.1001/archneur.1989.00520370037015
Abstract
• We have established an interleukin 2-dependent, OKT4-positive T-cell line, named HCT-1, from cells in the cerebrospinal fluid obtained from a patient with human T-cell lymphotropic virus type I (HTLV-1)-associated myelopathy. Antigens for HTLV-I were detected in HCT-1 cells by indirect immunofluorescence and Western blot testing, and type C virus particles were detected by electron microscopy. Southern blot analysis of HCT-1 cellular DNA, using an HTLV-I probe, revealed that the integrated provirus genome could not be distinguished from the HTLV-I genome in adult patients with T-cell leukemia.This publication has 7 references indexed in Scilit:
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