The Effect of Perinatal Thyroxine Treatment on the Development of the Plasma Corticosterone Diurnal Rhythm
- 1 January 1977
- journal article
- research article
- Published by S. Karger AG in Neuroendocrinology
- Vol. 24 (2), 65-73
- https://doi.org/10.1159/000122697
Abstract
Thyroxine (10 µg/g b.w., s.c), injected either on days 2, 3 and 4 or days 8, 9 and 10, resulted in a higher a.m.–p.m. plasma corticosterone difference on day 23, compared to the vehicle-treated controls. In a separate experiment the same dose of thyroxine on days 8, 9 and 10 caused an earlier appearance of significantly higher p.m. than a.m. plasma corticosterone levels (day 15 vs day 18 in vehicle-treated controls), and earlier eye-opening (12.38 ± 0.11 thyroxine vs l5.36±O.l4 days, vehicle). These results suggest that thyroxine influences the maturation of those neural structures which participate in the regulation of the diurnal rhythm of ACTH secretion and, as a consequence, in that of corticosterone production.Keywords
This publication has 5 references indexed in Scilit:
- Maternal influences on the ontogeny of basal levels of plasma corticosterone in the ratHormones and Behavior, 1976
- Decreased Pituitary Growth Hormone Content in Rats Treated Neonatally with High Doses of L-ThyroxineHormone and Metabolic Research, 1976
- Maturation of the Circadian Rhythm of Plasma Corticosterone in the RatEndocrinology, 1967
- Adrenal and Plasma Corticosterone and Vitamin A in Rat Adrenal Glands During Postnatal DevelopmentEndocrinology, 1967
- Fluorometric Determination of Corticosterone and Cortisol in 0.02–0.05 Milliliters of Plasma or Submilligram Samples of Adrenal Tissue1Endocrinology, 1964