Base Composition Differences between Avian Myeloblastosis Virus Transfer RNA and Transfer RNA Isolated from Host Cells
- 1 December 1971
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 68 (12), 3233-3237
- https://doi.org/10.1073/pnas.68.12.3233
Abstract
Using a novel chemical tritium derivative method, we have determined the base composition of 4S RNA isolated from an RNA tumor virus, the avian myeloblastosis virus, and from normal and neoplastic host cells. Extensive differences were detected, particularly with respect to the amount of methylated bases in the viral RNA. The viral 4S RNA, which fulfills the criteria for designation as transfer RNA, appears to be derived from a precursor pool that is different from the precursor population of host-cell 4S RNA. These results are discussed in regard to the possible relationship between transfer RNA of avian mycoblastosis virus and cellular transfer RNA.Keywords
This publication has 29 references indexed in Scilit:
- An investigation of the minor base composition of transfer RNA in normal human brain and malignant brain tumorsFEBS Letters, 1971
- Novel Species of tRNANature, 1971
- Involvement of 1‐Methyladenosine and 7‐Methylguanosine in the Three‐Dimensional Structure of (yeast)tRNAPheEuropean Journal of Biochemistry, 1971
- Viral DNA-dependent DNA Polymerase and the Properties of Thymidine Labelled Material in Virions of an Oncogenic RNA VirusNature, 1970
- Isolation of amino acid acceptor RNA from purified avian myeloblastosis virusJournal of Molecular Biology, 1970
- Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of RNA Tumour VirusesNature, 1970
- Analysis of nucleic acid derivatives at the subnanomole level. (V) High resolution mapping of tritium labelled RNA derivativesFEBS Letters, 1969
- Structure of a Mammalian Serine tRNANature, 1968
- RNA with high template activity from leukaemic myeloblasts (Bai strain a virus-induced avian myeloblastosis) I. Optimal conditions for its isolation and activity in the subcellular protein-synthesizing systemInternational Journal of Cancer, 1967
- The Structures of Two Serine Transfer Ribonucleic AcidsHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1966