Distinct Subcellular Localizations of Nox1 and Nox4 in Vascular Smooth Muscle Cells
Top Cited Papers
- 1 April 2004
- journal article
- research article
- Published by Wolters Kluwer Health in Arteriosclerosis, Thrombosis, and Vascular Biology
- Vol. 24 (4), 677-683
- https://doi.org/10.1161/01.atv.0000112024.13727.2c
Abstract
Objective— Reactive oxygen species (ROS) that act as signaling molecules in vascular smooth muscle cells (VSMC) and contribute to growth, hypertrophy, and migration in atherogenesis are produced by multi-subunit NAD(P)H oxidases. Nox1 and Nox4, two homologues to the phagocytic NAD(P)H subunit gp91phox, both generate ROS in VSMC but differ in their response to growth factors. We hypothesize that the opposing functions of Nox1 and Nox4 are reflected in their differential subcellular locations.Keywords
This publication has 34 references indexed in Scilit:
- Neutrophils with a License to Kill: Permeabilized, Not StirredDevelopmental Cell, 2003
- A Novel Assay System Implicates PtdIns(3,4)P2, PtdIns(3)P, and PKCδ in Intracellular Production of Reactive Oxygen Species by the NADPH OxidaseMolecular Cell, 2003
- Angiotensin II Stimulation of NAD(P)H Oxidase ActivityCirculation Research, 2002
- NAD(P)H Oxidases and Their Relevance to AtherosclerosisTrends in Cardiovascular Medicine, 2001
- Novel homologs of gp91phoxTrends in Biochemical Sciences, 2000
- Integrin SignalingScience, 1999
- Regulation of Src Family Tyrosine Kinase Activities in Adherent Human NeutrophilsJournal of Biological Chemistry, 1996
- A detergent-free method for purifying caveolae membrane from tissue culture cells.Proceedings of the National Academy of Sciences, 1995
- Cytochemical Localization of NAD(P)H Oxidase in the Myoepithelial Cells of Salivary and Other Exocrine Glands.ACTA HISTOCHEMICA ET CYTOCHEMICA, 1995
- Caveolin, a protein component of caveolae membrane coatsCell, 1992