The Polycomb complex PRC2 and its mark in life
Top Cited Papers
- 19 January 2011
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 469 (7330), 343-349
- https://doi.org/10.1038/nature09784
Abstract
Polycomb group proteins maintain the gene-expression pattern of different cells that is set during early development by regulating chromatin structure. In mammals, two main Polycomb group complexes exist — Polycomb repressive complex 1 (PRC1) and 2 (PRC2). PRC1 compacts chromatin and catalyses the monoubiquitylation of histone H2A. PRC2 also contributes to chromatin compaction, and catalyses the methylation of histone H3 at lysine 27. PRC2 is involved in various biological processes, including differentiation, maintaining cell identity and proliferation, and stem-cell plasticity. Recent studies of PRC2 have expanded our perspectives on its function and regulation, and uncovered a role for non-coding RNA in the recruitment of PRC2 to target genes.Keywords
This publication has 98 references indexed in Scilit:
- Comprehensive evaluation of the role of EZH2 in the growth, invasion, and aggression of a panel of prostate cancer cell linesThe Prostate, 2010
- Jarid2/Jumonji Coordinates Control of PRC2 Enzymatic Activity and Target Gene Occupancy in Pluripotent CellsCell, 2009
- A Vertebrate Polycomb Response Element Governs Segmentation of the Posterior HindbrainCell, 2009
- Polycomb Proteins Remain Bound to Chromatin and DNA during DNA Replication In VitroCell, 2009
- Ezh2 Orchestrates Gene Expression for the Stepwise Differentiation of Tissue-Specific Stem CellsCell, 2009
- H2AZ Is Enriched at Polycomb Complex Target Genes in ES Cells and Is Necessary for Lineage CommitmentCell, 2008
- Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAsCell, 2007
- High-Resolution Profiling of Histone Methylations in the Human GenomeCell, 2007
- Control of Developmental Regulators by Polycomb in Human Embryonic Stem CellsCell, 2006
- A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem CellsCell, 2006