PH1-Positive Chronic Myelogenous Leukemia, with Absence of Another G Chromosome, in a Male

Abstract

ALTERATIONS of smaller acrocentric chromosomes in malignant blood diseases have drawn much attention ever since the Philadelphia (PH¹) chromosome was noted in chronic myelogenous leukemia.^{1 , 2} In 1962 Atkin and Taylor³ described a fifty-three-year-old male patient with untreated chronic myelogenous leukemia whose blood cells had the PH¹ chromosome but also lacked a short acrocentric chromosome in the G group, either an autosome or the Y chromosome. In 2 other cases in males Tough et al.⁴ observed a similar pattern: in 1 patient, lack of a G group member was found in all cells with the PH¹ chromosome whereas in the . . .