Antidiuretic activities of substance P and its analogs
- 1 May 1981
- journal article
- research article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 37 (5), 521-523
- https://doi.org/10.1007/bf01986174
Abstract
Substance P (SP) and analogs, including 5 nucleoside (ARA or HRA)-peptides, were examined for antidiuretic activity in ethanolized rats. The activity was potent in the analogs embodying the C-terminal hexapeptide, weak in the nucleoside-pentapeptide, and negligible in the nucleoside-tetrapeptide. In addition, the activity was increased by acylation of the hexapeptide. The antidiuretic potencies were also compared with the hypotensive potencies.This publication has 22 references indexed in Scilit:
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