Dose-related effects of selective 5-HT2 receptor antagonists on slow wave sleep in humans
- 1 August 1990
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 101 (4), 568-569
- https://doi.org/10.1007/bf02244239
Abstract
The effects of the selective 5-HT2 receptor antagonists, ritanserin (1, 5 and 10 mg) and ICI 169,369 (50 and 100 mg), were studied on the sleep EEG of healthy volunteers using home-based Medilog 9000 cassette monitoring. Ritanserin (5 and 10 mg) produced a significant increase in slow wave sleep (SWS) while ICI 169,369 also increased SWS but only at a dose of 100 mg. These findings are consistent with the proposal that selective 5-HT2 receptor blockade increases SWS in humans; however, the data cannot exclude involvement of the closely related 5-HT1c receptor in this effect.This publication has 13 references indexed in Scilit:
- Pharmacological studies in vivo with ICI 169,369, a chemically novel 5-HT2/5-HT1C receptor antagonistEuropean Journal of Pharmacology, 1990
- Lithium increases slow wave sleep: possible mediation by brain 5-HT2 receptors?Psychopharmacology, 1989
- Increased slow wave sleep with 5-HT2 receptor antagonists: detection by ambulatory EEG recording and automatic sleep stage analysisJournal of Psychopharmacology, 1989
- Suppressant effects of selective 5-HT2 antagonists on rapid eye movement sleep in ratsBrain Research, 1989
- Molecular biology of 5-HT receptorsTrends in Pharmacological Sciences, 1989
- Molecular pharmacology and biology of 5-HT1C receptorsTrends in Pharmacological Sciences, 1988
- 5-HT2 receptors could be primarily involved in the regulation of slow-wabe sleep in the ratEuropean Journal of Pharmacology, 1987
- 5-Hydroxytryptamine-2 antagonist increases human slow wave sleepBrain Research, 1986
- Receptor binding profile of R 41 468, A novel antagonist at 5-HT2 receptorsLife Sciences, 1981
- [Effects of cyproheptadine on the sleep of normal man].1976